Andrew W. Grande, MD
- Stroke Care
- Neurosurgery Clinic
University of Minnesota, Minneapolis
University of Cincinnati (Neurosurgery)
University of Cincinnati (Vascular/Endovascular Neurosurgery); Ludwig-Maximilians University, Muenchen, Germany (Neural Stem Cells and Neurogenesis)
Dr. Andrew Grande originates from Minneapolis/St. Paul. He grew up in the Minneapolis lakes area and then later moved to St. Paul where he attended St. Thomas Academy for high school. He graduated from St. Olaf College (Northfield, MN) with a BA in chemistry and then attended the University of Minnesota Medical School. During college and medical school, he was very active in research activities at the University of Minnesota, working in the laboratories of Esam El. Fakahany, Virginia Seybold and Walter Low. These experiences later culminated in a burning curiosity and passion for the use of stem cells to treat stroke.
Dr. Grande completed his neurosurgical training at the Mayfield Clinic and University of Cincinnati. During his training, he worked very closely with Dr. John Tew, learning the nuances of trigeminal neuralgia treatment including both microvascular decompression and radiofrequency ablation. He then went on to complete a fellowship with Drs. Mario Zuccarello, Andrew Ringer and Todd Abruzzo at the University of Cincinnati in both endovascular and cerebrovascular neurosurgery. During this time, he had a significant exposure to intracranial bypass surgery for the treatment of Moya Moya disease and also cutting-edge endovascular treatments such as the use of Onyx glue for the treatment of cerebral aneurysms.
During his residency and then continuing into his fellowship, Dr. Grande was privileged to be involved in stem cell research with Professor Masato Nakafuku at Cincinnati Children’s Hospital. Professor Nakafuku was one of the first in the world to demonstrate neurogenesis in the hippocampus following stroke and he remains internationally recognized for his work with adult neurogenesis. In Professor Nakafuku’s laboratory, Dr. Grande’s research focused primarily on reprogramming cells within the cerebral cortex to form neurons following stroke. .
In 2010, Dr. Grande was the recipient of the William P. Van Wagenen Fellowship from the American Association of Neurological Surgeons. As a Van Wagenen Fellow, he traveled to Munich, Germany, where he completed a post-doctoral fellowship in the laboratory of Magdalena Gotz at Ludwig-Maximilians-Universitat. There he focused his research on identifying afferent connections to new neurons generated in the rodent cortex following a cortical layer specific injury.
Following his post-doctoral fellowship, Dr. Grande spent one month as a visiting Neurosurgeon with Professor Juha Hernesniemi in Helsinki, Finland.
Dr. Grande joined the University of Minnesota Department of Neurosurgery in 2011. His clinical interests are in the treatment of cerebral vascular diseases using either open vascular or endovascular techniques. He has specific interests in the treatment of complex aneurysms and Moya Moya disease. Additionally, Dr. Grande treats trigeminal neuralgia. Visit Dr. Grande's clinical web page.
Dr. Grande also directs the Earl Grande Stroke and Stem Cell Laboratory at the University of Minnesota. His research interest is focused on translating stem cell therapies for stroke from the bench to the bedside. Ongoing studies include exogenous cord blood stem cell transplantation for neuroprotection, reprogramming of reactive astrocytes to form neurons, and characterization of normal adult neural stem cells found in the brains of humans and other large animals.
Returning home to Minnesota, Dr. Grande is extremely committed and proud to treat Minnesota patients afflicted with neurological diseases.
“It has always been a dream of mine to be a neurosurgeon in Minnesota, in particular at the University of Minnesota. I was born and raised here, my entire family is here and there is nothing I enjoy more than interacting with Minnesota patients. When contemplating places to work, I only considered Minnesota; I just knew I could be a better neurosurgeon here. When facing neurosurgical diseases, I think there is something comforting in having a neurosurgeon with whom you have some connection.”
In the News
- A baby girl’s rare, life-threatening problem is solved by a highly skilled University team—and a strategic use of glue, November 5, 2013, University of Minnesota Foundation
- Trigeminal neuralgia surgery gives patients their lives back, April 26, 2013, Health Talk
- Neuroscience News, Fall 2011, pages 2-3, “Exploring what’s possible.”
- Fox 9 Interview, February 14, 2012, “University of Minnesota researchers in-utero stroke treatment.”
- HealthTalk, November 8, 2012, “The OR of the future is here today.”
- More Neurosurgery Department News
Dr. Grande also co-directs the Vel, Earl Grande, V. Richard Zarling Stroke, Stem Cell and Neuroimaging Laboratory at the University of Minnesota. His research interest is focused on the translation of stem cell therapies for stroke from the "bench to the bedside." Ongoing studies include exogenous cord blood stem cell transplantation for neuroprotection, reprogramming of reactive astrocytes to form neurons, and characterization of normal adult neural stem cells found in the brains of humans and other large animals.
- The National Science Foundation (Bin He, PI); (Andrew Grande, CO-I), “A Brain Centered Neuroengineering Approach for Motor Recovery after Stroke : Combined rTMS and BCI Training” ($321,360) September 1, 2013 – August 31, 2016
- IEM. (Co-I) “Nanotechnology Development and Applications for Clinical Neuroscience Applications” ($75,000) February 1, 2013 – January 31, 2014
- CURE Innovator Award (Heinrich, DePaulis, PI); (Andrew Grande, Collaborator), “Conversion of reactive glia into neurons in Mesial Temporal Lobe Epilepsy: a new way to generate GABAergic interneurons and reduce seizure activity?” ($75,000) June 1, 2013 – May 31, 2014
American Association of Neurological Surgeons (AANS)
- Member Benefit Development Committee, 2013 – present
- Section of Cerebrovascular Neurological Surgery, 2013 – present
- Council of State Neurosurgical Societies Liaison, 2011 – present
- Young Neurosurgeons Committee, 2008 – 2012
- Information Technology Committee Liaison, 2009 – 2012
- History Section Liaison, 2010 – 2012
Council of State Neurosurgical Societies
- AANS Caucus Member, 2010 – present
- Resident Fellow, 2007 – 2008
Congress of Neurological Surgeons
- Neurosurgery Watch, 2013 – present
- Education Committee, 2012 – present
- Council of State Neurosurgical Societies
- Resident Fellow, 2007 – 2008
- Minnesota Brain Injury Alliance, Board Member, 2013 – present
- Minnesota Stroke Conference Annual Meeting Planning and Partnership Committees, 2011 – present
- University of Minnesota Medical Center OR IT Committee, 2012 – present
- Champions of Care Award Recipient, Fairview Foundation, 2012
- William P Van Wagenen Fellow, 2010
- Ellen and Stewart B. Dunsker, MD, Award for Clinical Research, 2009
- The University Hospital Health Alliance Doctor’s Day Award, 2006
- Lopez-Juarez A, Howard J, Ullom K, Howard L, Grande A, Pardo A, Waclaw R, Sun YY, Yang D, Kuan CY, Campbell K, and Nakafuku M. (2013) Gsx2 Controls Region-Specific Activation of Neural Stem Cells and Injury-Induced Neurogenesis in the Adult Subventricular Zone. Genes Dev. 27(11):1272-87. PMID: 23723414
- Grande A, Sumiyoshi K, Lopez-Juarez A, Howard J, Sakthivel B, Aronow B, Campbell K and Nakafuku M. (2013) Environmental Impact on Direct Neuronal Reprogramming In Vivo in the Adult Brain. Nat. Commun. 2013 Aug 23;4:2372. PMID: 23974433
- Stone LL, Grande A, Low WC. (2013) Neural Repair and Neuroprotection with Stem Cells in Ischemic Stroke. Brain Sci. 3:599-614. doi:10.3390/brainsci3020599
- Nakafuku M, Nagao M, Grande A, Cancelliere A. (2008) Revisiting Neural Stem Cell Identity. Proc Natl Acad Sci. 105(3): 829-30. PMID: 18195367
- Nan Z, Grande A, Sanberg C, Sanberg P, Low W. (2005) Infusion of Human Umbilical Cord Blood Ameliorates Neurologic Deficits in Rats with Hemorrhagic Brain Injury. Ann. N.Y. Acad. Sci. 1049:84-96. PMID: 15965109
- Rodrigues C, Spellman S, Sola S, Grande A, Cheryle L, Low W, Steer C. (2002) Neuroprotection by Bile Acid in an Acute Stroke Model of Rat. J. Cerebral Blood Flow. 22:463-471. PMID: 119195117
- Wotta D. R, Parsons A. M, Hu J, Grande A. W., El-Fakahany E. E (1998) M1 Muscarinic Receptors Stimulate Rapid and Prolonged Phases of Neuronal Nitric Oxide Synthase Activity: Involvement of Different Calcium Pools. J. Neurochem. 71: 487-497. PMID: 9681438
- Jagadeesan B, Grigoryan M, Hassan A, Grande A, Tummala R. (2013) Endovascular Balloon-Assisted Embolization of Intracranial and Cervical Arteriovenous Malformations Using Dual Lumen Co-axial Balloon Microcatheters and Onyx. Neurosurgery DOI 10.1227/NEU.0b013e31828d602b
- Krishnan D, Alto D, Waisath T, Grande A, Khan U, Abruzzo T. (2011) Internal Carotid Artery Pseudoaneurysm After Le Fort I Osteotomy: Report of a Case and Its Management. J Oral Maxillofac Surg 69:e242-e245. PMID: 21605792
- Hsieh P, Ondrej S, Grande A, O’Shaughnessy B, Bierbrauer K, Crone K, Halpin R, Suk I, Koski T, Gokaslan Z, Kuntz IV C. (2009) Posterior Vertebral Column Subtraction Osteotomy (PVCSO): A Novel Surgical Approach for the Treatment of Multiply Recurrent Tethered Cord Syndrome (TCS). J Neurosurg Spine 10(4): 278-286. PMID: 19441983
- Air E, Ghomri Y, Tyagi R, Grande A, Crone K, Mangano F. (2009) Management of Vagal Nerve Stimulator Infections: Do They Need to be Removed. J Neurosurg Pediatr 3(1): 73-8 PMID: 19119910
- Grande A, Maher P, Morgan C, Choutka O, Ling B., Raderstorf T, Berger E, Kuntz IV C. (2006) Vertebral Column Subtraction Osteotomy for Recurrent Tethered Cord Syndrome in Adults: a Cadaveric Study. J Neurosurg Spine. 4: 478-484. PMID: 16776359
Chapters in Books
- Stone LL, Low WC, Grande A. Stem Cell Therapies for Ischemic Stroke, in Laurent Lescaudron, Julien Rossignol, Gary L. Dunbar, eds. Stem Cells and Neurodegenerative Diseases, CRC Press (2013)
- Nakafuku M, Grande A. (2013) Neurogenesis in the Damaged Mammalian Brain, Chapter 29. In John Rubenstein and Pasko Rakic, eds. Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Developmental Neuroscience. Elsevier/Academic Press.
- Morgan C, Grande A, Tew J. (2012) Percutaneous Stereotactic Rhizotomy in the Treatment of Intractable Facial Pain, Chapter 124. In Alfredo Quinones-Hinojosa ed. Schmidek & Sweet, Sixth Edition. Elsevier/Saunders
- Ringer A, Nichols C, Khan S, Grande A, Khan U, Pyne-Geithman G, Abruzzo T. (2011) Angioplasty and Stenting for Management of Intracranial Arterial Stenosis. Hemorrhagic and Ischemic Stroke: Surgical, Interventional, Imaging, and Medical Approaches. Hemorrhagic and Ischemic Stroke: Medical, Imaging, Surgical and Interventional Approaches, Eds Bernard Bendok, Andrew Naidech, Matt Walker, and H. Hunt Batjer. Thieme
- Nakafuku M, Grande A. (2011) Neurogenesis in the Damaged Mammalian Brain. Comprehensive Developmental Neuroscience, Chapter 74. Eds. Pasko Rakic and John Rubenstein. Elsevier Inc (Amsterdam)
- Morgan C, Grande A, Tew J. (2011) Percutaneous Stereotactic Rhizotomy in the Treatment of Intractable Facial Pain. Schmidek & Sweet, Sixth Edition
- Grande A, Nichols C, Khan U, Abruzzo T, Ringer A, Zuccarello M. (2011) Treatment of Post-Hemorrhagic Cerebral Vasospasm: role of endovascular therapy. Early Brain Injury or Cerebral Vasospasm, Acta Neurochirurgica Supplementum, Supplement Volume 110/2
- Grande A., Morgan C., Tew J. (2011) Percutaneous Stereotactic Rhizotomy. Trigeminal Neuralgia Ed. Peter Jennetta. Oxford University Press (New York)
- Tew J., Grande A., (2008) Percutaneous Stereotactic Radiofrequency Treatment of Trigeminal Neuralgia. COSMAN Procedure Technique Series
- Choutka O., Grande A., Kuntz IV C. (2006) Posterior Thoracic Instrumentation with Pedicle Screws, Hooks, Wires, and Rods. Neurosurgical Operative Atlas, Spine and Peripheral Nerve
Other Published Articles
- Grande A, Tummala R, Jagadeesan B. (2012) Carotid Artery Disease: Heading to the OR to Reduce the Risk of Stroke. Minnesota Physician 26(5)
- Grande A. (2013) Making the Leap from Bench to Bedside: The Promise and Present State of Stem Cell Therapy in Treating Stroke. Minnesota Physician 26(11)