Selected Publications

PUBLICATIONS (The following publications have received over 5,130 citations in the scientific literature)

1. Low WC: Analysis of Neurophysiological Plasticity within the Hippocampal Formation. University Microfilms, Xerox Corporation, Ann Arbor, Michigan, 1979.

2. Low WC and BeMent SL: Enhancement of afferent fiber activity in hippocampal slices. Brain Res 198: 472-477, 1980. 

3. Dunnett SB, Gage FH, Bjorklund A, Stenevi U, Low WC and Iversen SD: Hippocampal deafferentiation: Transplant-derived reinnervation and functional recovery. Scand J Psychol Suppl. 1: 104-111, 1982.

4. Dunnett SB, Low WC, Iversen SD, Stenevi U and Bjorklund A: Septal transplants restore maze learning in rats with fornix-fimbria lesions. Brain Res 251: 335-348, 1982.  Abstract (HTML) Full Text (PDF)

5. Low WC, BeMent SL and Whitehorn D: Periodic fluctuations in synaptic transmission and enhancement of transmission in hippocampal slices. Brain Res 231: 438-443, 1982.  Abstract (HTML) Full Text (PDF)

6. Low WC, Lewis PR, Bunch ST, Dunnett SB, Thomas SR, Iversen SD, Bjorklund A and U. Stenevi: Function recovery following neural transplantation of embryonic septal nuclei in adult rats with septohippocampal lesions. Nature 300: 260-262, 1982.          Full Text (PDF)

7. Garsik JT, Low WC and Whitehorn D: Differences in transmission through the dorsal column nuclei in spontaneously hypertensive and Wistar Kyoto rats. Brain Res 271: 188-192, 1983.  Abstract (HTML)

8. Low WC, BeMent SL and Whitehorn D: Field potential evidence for extrasynaptic alterations in the hippocampal CA1 pyramidal cell population during paired pulse potentiation. Exp Neurol 80: 9-22, 1983.  Abstract (HTML)

9. Low WC, Lewis PR and Terri ST: Embryonic neural transplants across a major histocompatibility barrier: survival and specificity of innervation. Brain Res 262: 328-333, 1983.   Abstract (HTML)   Full Text (PDF)

10. Whitehorn D, Atwater DG, Low WC, Gellis JE and Hendley ED: Independence of blood pressure and locomotor activity in normotensive  and genetically hypertensive rat. Behav Neural Biol 37: 357-361, 1983.  Abstract (HTML)  Full Text (PDF)

11. Dunnett SB, Gage FH, Bjorklund A, Stenevi U, Low WC, and Iversen SD: Hippocampal deafferentiation: Transplant-derived reinnervation and functional recovery. Acta Psychiatr Scand Suppl 313: 46-56, 1984.          Abstract (HTML)

12. Garsik JT, Low WC and Whitehorn D: Alterations of evoked potentials in the medial lemniscus of the rat due to acute and chronic elevations in blood pressure. Brain Res 306: 380-383, 1984.          Abstract (HTML)          Full Text (PDF)

13. Low WC, Hendley ED and Whitehorn D: Genetically related rats with differences in hippocampal uptake of norepinephrine and maze performance. Brain Res Bull 12: 703-709, 1984.          Abstract (HTML)          Full Text (PDF)

14. Daniloff JK, Bodony RP, Low WC and Wells J: Cross-species embryonic septal transplants: restoration of conditioned learning behavior. Brain Res 346: 176-180, 1985.          Abstract (HTML)          Full Text (PDF)

15. Daniloff JR, Low WC, Bodony RP and Wells J: Cross-species neural transplants of embryonic septal nuclei to the hippocampal formation of adult rats. Exp Brain Res 59: 73-82, 1985.          Abstract (HTML)          Full Text (PDF)

16. Hendley ED, Wessel DJ, Atwater DG, Gellis J, Whitehorn D and Low WC: Age, sex and strain differences in activity and habituation in SHR and WKY rats. Physiol Behav 34: 379-383, 1985.          Abstract (HTML)          Full Text (PDF)

17. Low WC, Daniloff JK, Bodony RP and Wells J, Cross-species transplants of cholinergic neurons and the recovery of function, Neural Grafting in the Mammalian CNS, Ed. by A. Bjorklund and U. Stenevi, Elsevier Science Publ., Amsterdam, pp. 575-584 (1985).

18. Triarhou LC, Low WC, and Ghetti B: Transplantation of ventral mesencephalic analgen to hosts with genetic nigrostriatal dopamine deficiency. Proc Natl Acad Science 83: 8789-8793, 1986.          Abstract (HTML)          Full Text (PDF)

19. Kaseda Y, Ghetti B, Low WC, Richter JA, and Simon JR: Dopamine D2 receptors increase in the dorsolateral striatum of weaver mutant mice. Brain Res 422: 178-181, 1987.          Abstract (HTML)          Full Text (PDF)

20. Low WC, Triarhou LC, and Ghetti B: Cerebellar transplants into mutant mice with Purkinje and granule cell degeneration. Ann N Y Acad Sci 495: 740-744, 1987.

21. Low WC, Triarhou LC, Kaseda Y, Norton J, and Ghetti B: Functional innervation of the striatum by ventral mesencephalic grafts in mice with inherited nigrostriatal dopamine deficiency. Brain Res 435: 315-321, 1987.          Abstract (HTML)          Full Text (PDF)

22. Triarhou LC, Low WC, and Ghetti B: Synaptic investment of striatal cellular domains by grafted dopamine neurons in mutant weaver mice. Naturwissenschaften 74: 591-593, 1987.

23. Triarhou LC, Low WC and Ghetti B: Transplantation of cerebellar anlagen to hosts with genetic cerebellocortical atrophy. Anat Embryol (Berl) 176: 145-154, 1987.          Abstract (HTML)          Full Text (PDF)

24. Farber SD, Onifer SM, Kaseda Y, Murphy SH, Wells DG, Vietje BP, Wells J, and Low WC: Neural transplantation of horseradish peroxidase-labeled hippocampal cell suspensions in an experimental model of cerebral ischemia. Prog Brain Res 78: 103-107, 1988.          Full Text (PDF)

25. Triarhou LC, Low WC, and Ghetti B, Genetic mesotelencephalic dopamine deficiency in weaver mutant mice: Reinstatement of neuronal connectivity by solid grafts of foetal mesencephalon, In: New Trends in Aging Research, Ed. by G. Pepeu, B. Tomlinson, and C.M. Wischik, Liviana Press, Padova, pp.183-192 (1988).

26. Triarhou LC, Low WC, and Ghetti B: Layer-specific innervation of the dopamine-deficient frontal cortex of weaver mutant mice by grafted mesencephalic dopaminergic neurons. Cell Tissue Res 254: 11-15, 1988.          Abstract (HTML)

27. Triarhou LC, Low WC, Norton J, and Ghetti B: Reinstatement of synaptic connectivity in the striatum of weaver mutant mice following transplantation of ventral mesencephalic anlagen. J Neurocytol 17: 223-243, 1988.          Abstract (HTML)

28. Chang AC, Triarhou LC, Alyea CJ, Low WC, and Ghetti B: Developmental expression of polypeptide PEP-19 in cerebellar cell suspensions transplanted into the cerebellum of pcd mutant mice. Exp Brain Res 76: 639-645, 1989.          Abstract (HTML)          Full Text (PDF)

29. Kaseda Y, Simon JR, Low WC: Restoration of high affinity choline uptake in the hippocampal formation following septal cell suspension transplants in rats with fimbria-fornix lesions. J Neurochem 53: 482-488, 1989.          Abstract (HTML)

30. Kubek MJ, Low WC, Sattin A, Morzorati SL, Meyerhoff JL, and Larsen SH: Role of TRH in seizure modulation. Ann N Y Acad Sci 553: 286-303, 1989.

31. Low WC, Central integrative systems, In: Human Physiology, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 354-373 (1989).

32. Low WC, Farber SD, Hill TG, Sattin A, and Kubek MJ: Evidence for extrinsic and intrinsic sources of thyrotropin-releasing hormone (TRH) in the hippocampal formation as determined by radioimmunoassay and immunocytochemistry. Ann N Y Acad Sci 553: 574-578, 1989.

33. Low WC, Functional organization of the nervous system, In: Human Physiology,
Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp.211-253 (1989).

34. Low WC, Motor systems, In: Human Physiology, Ed., by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 304-332 (1989).

35. Low WC, Roepke J, Farber SD, Hill TG, Sattin A, and Kubek MJ: Distribution of thyrotropin-releasing hormone (TRH) in the hippocampal formation as determined by radioimmunoassay. Neurosci Lett 103: 314-319, 1989.          Abstract (HTML)          Full Text (PDF)

36. Low WC, Sensory systems, In: Human Physiology, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 254-303 (1989).

37. Low WC, The autonomic nervous system, In: Human Physiology, Ed., by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp.333-353 (1989).

38. Murai I, Low WC, and Ben-Jonathan N: Microsurgical techniques for studying functional correlates of the hypothalamohypophyseal axis. Methods Enzymol 168: 234-254, 1989.

39. Wagner WW, Low WC, Meiss RA, Peavy DE, Tanner GA, Kempson SA, Pflanzer RG, and Rhoades RA, The science of physiology, In: Human Physiology, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 1-25 (1989).

40. Gage SL, Keim SR, and Low WC: Effects of insulin-like growth factor II (IGF-II) on transplanted cholinergic neurons from the fetal septal nucleus. Prog Brain Res 82: 73-80, 1990.          Full Text (PDF)

41. Gage SL, Keim SR, and Low WC, Trophic influence of insulin-like growth factor II (IGF-II) on grafted cholinergic neurons from the fetal septal nucleus, In: Brain Aging, Molecular Neurobiology, the Aging Process, and Neurodegenerative Diseases, Ed. by
H. Hendrie, L. Mendelsohn, and C. Readhead, Hogrefe & Huber Publishers, Toronto,
pp. 269-273 (1990).

42. Ghetti B, Triarhou LC, Alyea CJ, Low WC, and Chang AC: Timing of neuronal replacement in cerebellar degenerative ataxia of Purkinje cell type. Prog Brain Res 82: 197-202, 1990.         Full Text (PDF)

43. Kaseda Y, Ghetti B, Low WC, Norton J, Brittain H, Triarhou LC, Richter JA, and Simon JR: Age-related changes in striatal dopamine D2 receptor binding in weaver mutant mice and effects of ventral mesencephalic grafts. Exp Brain Res 83: 1-8, 1990.        Abstract (HTML)          Full Text (PDF)

44. Kaseda Y, Simon JR, and Low WC, Evidence for functional innervation of transplanted cholinergic neurons by GABAergic afferents as determined by high-affinity choline uptake, In: Brain Aging, Molecular Neurobiology, the Aging Process, and Neurodegenerative Diseases, Ed. by H. Hendrie, L. Mendelsohn, and C. Readhead, Hogrefe & Huber Publishers, Toronto, pp. 277-282 (1990).

45. Kaseda Y, Simon JR, and Low WC: GABAergic modulation of cholineric septal neurons transplanted to the hippocampal formation. International Journal of Neurology 24: 174-181, 1990.

46. Onifer SM and Low WC, Cerebral ischemia and restoration of function with intrahippocampal transplants of fetal hippocampal neurons in Mongolian gerbils, In: Brain Aging, Molecular Neurobiology, the Aging Process, and Neurodegenerative Diseases, Ed. by H. Hendrie, L. Mendelsohn, and C. Readhead, Hogrefe & Huber Publishers, Toronto, pp. 283-287 (1990).

47. Onifer SM and Low WC: Spatial memory deficits resulting from ischemia-induced damage to the hippocampus are ameliorated by intrahippocampal transplants of fetal hippocampal neurons. Prog Brain Res 82: 359-366, 1990.          Full Text (PDF)

48. Triarhou LC, Low WC, and Ghetti B: Dopamine neurone grafting to the weaver mouse neostriatum. Prog Brain Res 82: 187-195, 1990.

49. Tarricone BJ, Keim SR, Simon JR, and Low WC: Intrahippocampal transplants of septal cholinergic neurons: High-affinity choline uptake and spatial memory function. Brain Res 548: 55-62, 1991.          Abstract (HTML)

50. Li YJ, Simon JR, and Low WC: Intrahippocampal grafts of cholinergic-rich striatal tissue ameliorate spatial memory deficits in rats with fornix lesions. Brain Res Bull 29: 147-155, 1992.          Abstract (HTML)

51. Low WC, Central integrative systems, In: Human Physiology, 2nd Edition, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 396-417 (1992).

52. Low WC, Functional organization of the nervous system, In: Human Physiology, 2nd Edition, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 234-282 (1992).

53. Low WC, Motor systems, In: Human Physiology, 2nd Edition, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 338-370, (1992).

54. Low WC, Sensory systems, In: Human Physiology, 2nd Edition, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 283-337, (1992).

55. Low WC, The autonomic nervous system, In: Human Physiology, 2nd Edition, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 371-395 (1992).

56. Rhoades RA, Low WC, Meiss RA, Peavy DE, Tanner GA, Kempson SA, Pflanzer RG, The science of physiology, In: Human Physiology, 2nd Edition, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 1-29 (1992).

57. Sattin A, Kubek MJ, Low WC, Staley CJ, and Simon JR: Some regional anatomical relationships of TRH and 5-HT in rat limbic forebrain. Neurochem Res 17: 469-473, 1992.          Abstract (HTML)

58. Triarhou LC, Low WC, and Ghetti B: Intraparenchymal grafting of cerebellar cell suspensions to the deep cerebellar nuclei of pcd mutant mice, with particular emphasis on re-establishment of a Purkinje cell cortico-nuclear projection. Anat Embryol (Berl), 185: 409-420, 1992.          Abstract (HTML)

59. Triarhou LC, Low WC, and Ghetti B: Serotonin fiber innervation of cerebellar cell suspensions intraparenchymally grafted to the cerebellum of pcd mutant mice. Neurochem Res 17: 475-482, 1992.          Abstract (HTML)          Full Text (PDF)

60. Triarhou LC, Low WC, Doucet G, Brudin P, Bjorklund A, and Ghetti B, The weaver mutant mouse as a model for intrastriatal grafting of fetal dopamine neurons, ed. by F.Hefti and W.J. Weiner, Progress in Parkinson's Research, pp. 389-400 (1992).

61. Sola C, Mengod G, Low WC, Norton J, Ghetti B, Palacios JM, and Triarhou LC: Regional distribution of amyloid beta-protein precursor, growth-associated phosphoprotein-43 and microtubule-associated protein 2 messenger RNAs in the nigrostriatal system of normal and Weaver mutant mice and effects of ventral mesencephalic grafts. Eur J Neurosci, 5: 1442-1454, 1993.          Abstract (HTML)

62. Tarricone BJ, Simon JR, and Low WC: Intrahippocampal transplants of septal cholinergic neurons: choline acetyltransferase activity, muscarinic receptor binding, and spatial memory function. Brain Res 632: 41-47, 1993.          Abstract (HTML)          Full Text (PDF)

63. Eastlund T, Low WC and Mooradian D: Isolation and culture of osteoblast progenitors from human fetal calvarium. Transplant Proc 26: 4000-4001, 1994.

64. Gage SL, Keim SR, Simon JR, and Low WC: Cholinergic innervation of the retrosplenial cortex via the fornix pathway as determined by high affinity choline uptake, choline acetyltransferase activity and muscarinic receptor binding in the rat. Neurochem Res 19: 1379-1386, 1994.          Abstract (HTML)          Full Text (PDF)

65. Kondoh T and Low WC: Glutamate uptake blockade induces striatal dopamine release in 6-hydroxydopamine rats with intrastriatal grafts: evidence for host modulation of transplanted dopamine neurons. Exp Neurol 127: 191-198, 1994.          Abstract (HTML)          Full Text (PDF)

66. Kondoh T, Blount JP, Conrad JA, Pundt LP and Low WC: Functional effects of transplanted human fetal ventral mesencephalic brain tissue from spontaneous abortions into a rodent model of Parkinson's disease. Transplant Proc. 26: 3335, 1994.        Full Text (PDF)

67. Kondoh T, Korosue K, Lee SH, Heros RC, and Low WC: Evaluation of monoaminergic neurotransmitters in the rat striatum during varied global cerebral ischemia. Neurosurgery 35: 278-286, 1994          Abstract (HTML)          Full Text (PDF)

68. Li YJ, Conrad JA, and Low WC: Transplantation of cholinergic-rich spinal tissue from spontaneously aborted human fetuses into a rodent model of Alzheimer's disease. Transplant Proc 26(6): 3336, 1994.          Abstract (HTML)          Full Text (PDF)

69. Low WC, Eastlund T, Verfaillie C, Hirschel M, Virnig B, Weese K, Norris B, Chrysler G, Peterson A and Forbes J: Human fetal tissue from spontaneous abortions as potential sources of donor tissue for cell transplantation therapies. Transplant Proc 26: 4100, 1994.

70. Pundt LL, Kondoh T and Low WC: NADPH-Diaphorase histochemistry and functional analysis of human fetal striatal tissue transplanted into a rodent model of Huntington's disease. Transplant Proc 26(6): 3296, 1994.

71. Triarhou LC, Stotz EH, Low WC, Norton J, Ghetti B, Landwehrmeyer B, Palacios JM and Simon JR: Studies on the striatal dopamine uptake system of weaver mutant mice and effect of ventral mesencephalic grafts. Neurochem Res 19: 1349-1358, 1994.        Abstract (HTML)

72. Blount JP, Kondoh T, Pundt L, Conrad J, Jansen E and Low WC: Immunobiology of neural transplants and functional incorporation of grafted dopamine neurons. Behavioral and Brain Sciences 18: 48-49, 1995.          Full Text (PDF)

73. Branch DW, Ducat L, Fantel A, Low WC, Zhou F, Dayton D and Gill T: Suitability of fetal tissues from spontaneous abortions and from ectopic pregnancies for transplantation. JAMA 273: 66-68, 1995.          Abstract (HTML)          Full Text (PDF)

74. Chesney JA, Kondoh T, Conrad JA, and Low WC: Collagenase-induced intrastriatal hemorrhage in rats results in long-term locomotor deficits. Stroke 26: 312-317, 1995.          Abstract (HTML)          Full Text (PDF)

75. Chiang L, Flores E, Wen D, Hall W and Low WC: Gene therapy for neurodegenerative disorders and malignant brain tumors. Behavioral and Brain Sciences 18: 52-53, 1995.          Full Text (PDF)

76. Jansen EM and Low WC, Plasticity and reorganization in neural injury and neural grafting, In: Threats to Optimal Developmet: Integrating Biological, Psychological, and Social Risks, Ed. by C.A. Nelson, New Jersey-Lawrence Erlbaum Press, pp. 33-58, (1995).

77. Kondoh T, Lee SH, and Low WC: Alterations in striatal dopamine release and reuptake under conditions of mild, moderate, and severe cerebral ischemia. Neurosurgery 37: 948-954, 1995.          Abstract (HTML)          Full Text (PDF)

78. Kondoh T, Pundt L, and Low WC: Development of human fetal ventral mesencephalic grafts in rats with 6-OHDA lesions of the nigrostriatal pathway. Neurosci Res 21: 223-233, 1995.          Abstract (HTML)          Full Text (PDF)

79. Li YJ and Low WC: Intraretrosplenial grafts of cholinergic neurons and spatial memory function. Behavioral and Brain Sciences 18: 61-62, 1995.

80. Low WC and Hendley ED, The action potential and synaptic transmission, In: Medical Physiology, Ed. by R.A. Rhoades and G.A. Tanner, Little Brown, Publ, Boston pp. 33-58, (1995).

81. Low WC: Guest Editor, Guidelines and regulations for cell transplantation therapies, Cell Transplant 4: 439, 1995.          Full Text (PDF)

82. Madhavan PG, Stephens BE, and Low WC: Tri-State neural network and analysis of its performance. Intellegent Automation and Soft Computing 1: 235-246, 1995.

83. Pundt LL, Kondoh T, and Low WC: The fate of human glial cells following transplantation in normal rodents and rodent models of neurodegenerative disease. Brain Res 695: 25-36, 1995.          Abstract (HTML)          Full Text (PDF)

84. Efange SM, Langason RB, Khare AB, and Low WC: The vesamicol receptor ligand (+)-meta- [125]iodobenzyltrozamicol{(+)-[125]-MIBT} reveals blunting of the striatal cholinergic response to dopamine D2 receptor blockade in the 6-hydroxydopamine (6-OHDA)-lesioned rat: possible implications for Parkinson?s disease. Life Sci 58: 1367-1374, 1996.          Abstract (HTML)          Full Text (PDF)

85. Hall WA, Flores EP, and Low WC: Antisense oligonucleotides for central nervous system tumors. Neurosurgery 38: 376-383, 1996.          Abstract (HTML)          Full Text (PDF)

86. Jansen EM and Low WC: Long term effects of neonatal ischemic-hypoxic brain injury on sensorimotor and locomotor tasks in rats. Behav Brain Res 78: 189-194, 1996.          Abstract (HTML)          Full Text (PDF)

87. Jansen EM and Low WC: Quantitative analysis of contralateral hemisphere hypertrophy and sensorimotor performance in adult rats following unilateral neonatal ischemic-hypoxic brain injury. Brain Research 708: 93-99, 1996.          Abstract (HTML)          Full Text (PDF)

88. Kondoh T, Pundt LL, Blount JP, Conrad JA, and Low WC: Transplantation of human fetal tissue from spontaneous abortions to a rodent model of Parkinson?s disease. Cell Transplant 5: 69-75, 1996.          Abstract (HTML)          Full Text (PDF)

89. Low WC, Central integrative systems, In: Human Physiology, 3rd Edition, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 351-371 (1996).

90. Low WC, Functional organization of the nervous system, In: Human Physiology, 3rd Edition, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 208-251 (1996).

91. Low WC, Motor systems, In: Human Physiology, 3rd Edition, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 298-327, (1996).

92. Low WC, Sensory systems, In: Human Physiology, 3rd Edition, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 252-297, (1996).

93. Low WC, The autonomic nervous system, In: Human Physiology, 3rd Edition, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 328-350 (1996).

94. Pundt LL, Kondoh T, Conrad JA, and Low WC: Transplantation of human fetal striatum into a rodent model of Huntington?s disease ameliorates locomotor deficits. Neurosci Res, 24: 415-420, 1996.          Abstract (HTML)          Full Text (PDF)

95. Pundt LL, Kondoh T, Conrad JA, and Low WC: Transplantation of human striatal tissue into a rodent model of Huntington?s Disease: phenotypic expression of transplanted neurons and host-to-graft innervation. Brain Res Bull 39: 23-32, 1996.          Abstract (HTML)          Full Text (PDF)

96. Rhoades RA, Low WC, Meiss RA, Peavy DE, Tanner GA, Kempson SA, Pflanzer RG, The science of physiology, In: Human Physiology, 3rd Edition, Ed. by R.A. Rhoades and R.G. Pflanzer, W.B. Saunders Company, Philadelphia, pp. 1-27 (1996).

97. Tarricone BJ, Simon JR, Li YJ, and Low WC: Neural grafting of cholinergic neurons in the hippocampal formation. Behav Brain Res 74: 25-44, 1996.          Abstract (HTML)          Full Text (PDF)

98. Yanaka K, Camarata PJ, Spellman SR, McCarthy JB, Furcht LT, Low WC, and Heros RC: Neuronal protection from cerebral ischemia by synthetic fibronectin peptides to leukocyte adhesion molecules. J Cereb Blood Flow Metab 16: 1120-1125, 1996.          Abstract (HTML)          Full Text (PDF)

99. Yanaka, K, Camarata PJ, Spellman SR, McCarthy JB, Furcht LT, Low WC, and Heros RC: Synthetic fibronectin peptides and ischemic brain injury after transient middle cerebral artery occlusion in rats. J Neurosurg 85: 125-130, 1996.  Abstract (HTML)          Full Text (PDF)

100. Yanaka K, Spellman SR, McCarthy JB, Low WC and Camarata PJ: Reduction of brain injury using heparin to inhibit leukocyte accumulation in a rat model of transient focal cerebral ischemia. II. Dose response effect and the therapeutic window. J Neurosurg 85: 1108-1112, 1996.          Abstract (HTML)          Full Text (PDF)

101. Yanaka K, Spellman SR, Oegema TR, McCarthy JB, Low WC and Camarata PJ: Reduction of brain injury using heparin to inhibit leukocyte accumulation in a rat model of transient focal cerebral ischemia. I. Protective mechanism. J Neurosurg 85: 1102-1107, 1996.          Abstract (HTML)          Full Text (PDF)

102. Jansen EM, Solberg L, Underhill S, Wilson S, Cozzari C, Hartman BK, Faris PL, and Low WC: Transplantation of fetal neocortex ameliorates sensorimotor and locomotor deficits following neonatal ischemic-hypoxic brain injury in rats. Exp Neurol 147: 487-497, 1997.          Abstract (HTML)          Full Text (PDF)

103. Li YJ and Low WC: Intra-retrosplenial cortical grafts of cholinergic neurons: functional incorporation and restoration of high affinity choline uptake. Neurochem Res 22: 589-595, 1997.          Abstract (HTML)          Full Text (PDF)

104. Li YJ and Low WC: Intraretrosplenial cortical grafts of fetal cholinergic neurons and the restoration of spatial memory function. Cell Transplant 6: 85-93, 1997.          Abstract (HTML)          Full Text (PDF)

105. Li YJ, Hartman BK, Faris PL, and Low WC: Specificity of fiber innervation by cholinergic neurons transplanted into the retrosplenial cortex of adult rats as revealed by cholineacetyltransferase immunocytochemistry. Restorative Neurology and Neuroscience 11: 99-108, 1997.          Full Text (PDF)

106. Pundt LL, Jorn EA, Conrad JA, and Low WC: Organization and histochemical phenotype of human fetal cerebellar cells following transplantation into the cerebellum of nude mice. Cell Transplant 6: 479-489, 1997.          Abstract (HTML)          Full Text (PDF)

107. Pundt L, Narang N, Kondoh T, and Low WC: Localization of dopamine receptors and associated mRNA in transplants of human fetal striatal tissue in rodents with experimental Huntington?s disease. Neurosci Res 27: 305-315, 1997.          Abstract (HTML)          Full Text (PDF)

108. Yanaka K, Camarata PJ, Spellman SR, McCarthy JB, Furcht LT and Low WC:  Antagonism of leukocyte adherence by synthetic fibronectin peptide V in a rat model of transient focal cerebral ischemia, Neurosurgery 40: 557-563, 1997.          Abstract (HTML)          Full Text (PDF)

109. Yanaka K, Camarata PJ, Spellman SR, Skubitz AP, Furcht LT, and Low WC: Laminin peptide ameliorates brain injury by inhibiting leukocyte accumulation in a rat model of transient focal cerebral ischemia. J Cereb Blood Flow Metab 17: 605-611, 1997.          Abstract (HTML)

110. Jean WC, Spellman SR, Nussbaum ES, and Low WC: Reperfusion injury after focal cerebral ischemia: the role of inflammation and the therapeutic horizon. Neurosurgery 43: 1382-1396, 1998.          Abstract (HTML)          Full Text (PDF)

111. Jean WC, Spellman SR, Wallenfriedman MA, Hall WA: Interleukin-12 based immunotherapy against rat 9L glioma. Neurosurgery 42(4): 850-857, 1998.          Abstract (HTML)          Full Text (PDF)

112. Hall WA, Flores EP, Low WC, Antisense oligodeoxynucleotide targets, In: The Gliomas, M.S. Berger and C.B. Wilson, (Eds.) Williams and Wilkins, Baltimore, pp. 165-173 (1999).

113. Kaemmerer WF and Low WC: Cerebellar allografts survive and transiently alleviate ataxia in a transgenic model of spinocerebellar ataxia type-1. Exp Neurol 158: 301-311, 1999.          Abstract (HTML)          Full Text (PDF)

114. Wallenfriedman MA, Conrad JA, DelaBarre L, Graupman PC, Lee G, Garwood M, Gregerson DS, Jean WC, Hall WA, and Low WC: Effects of continuous localized infusion of granulocyte/macrophage colony stimulating factor (GM-CSF) and inoculations of irradiated glioma cells on tumor regression. J Neurosurg 90: 1064-1071, 1999.          Abstract (HTML)          Full Text (PDF)

115. Duan WM, Zhao LR, Westerman M, Lovick D, McCarthy J, and Low WC: Enhancement of nigral graft survival in rat brain with the systemic administration of synthetic fibronectin peptide V. Neuroscience 100: 521-530, 2000.          Abstract (HTML)          Full Text (PDF)

116. Kaemmerer WF, Reddy RG, Warlick CA, Hartung SD, Zolotukhin S, McIvor RS, and Low WC: In vivo transduction of cerebellar Purkinje Cells using adeno-associated virus vectors. Mol Ther 2: 446-457, 2000.          Abstract (HTML)          Full Text (PDF)

117. Kim KU, Ni HT, W.C. Low, and W.A. Hall: Growth factor receptor expression on brain tumor cell lines: Preliminary study for in vitro and in vivo experiments of immunotoxin therapy. Journal of the Korean Neurosurgical Society 29: 731-739, 2000.          Full Text (PDF)

118. Kim KU, Vallera DA, Ni HT, Cho KH, Low WC, and Hall WA: In vitro efficacy of recombinant diphtheria toxin-murine interleukin-4 conjugate on mouse glioblastoma and neuroblastoma cell lines and its additive effect with irradiation. Neurosurgical Focus 9(6): Article 5, 2000.          Full Text (PDF)

119. Low WC and Li YJ, Intrahippocampal grafts of cholinergic neurons: Survival, innervation, and functional restoration, In: Intracerebral Transplantation, Ed. by Q.Y. Wu and S.-S Jiao, The Science Press, Beijing, pp. 108-113 (2000).

120. Low WC and Li YJ, Methods of neural transplantation to repair damaged neuronal circuitry, In: Intracerebral Transplantation, Ed. by Q.Y. Xu and S.-S. Jiao, The Science Press, Beijing, pp. 24-32 (2000).

121. Low WC and Li YJ, Neural transplantation of dopamine-containing tissue into the striatum of animals with nigrostriatal dopamine deficits, In: Intracerebral Transplantation, Ed. by Q.Y. Wu and S.-S Jiao, The Science Press, Beijing, pp. 78-85 (2000).

122. Low WC, Duan WM, Keene CD, Ni HT, and Westerman MA, Immunobiology of neural xenotransplantation, In: Neuromethods, Vol. 36: Neural Transplantation Methods, Ed. by S.B. Dunnett, A.A. Boulton, and G.B. Baker, Humana Pres Inc., Totowa, NJ pp. 503-541 (2000).

123. Ni HT, Merica RR, Spellman SR, and Low WC: Visualization of antigen-specific T cell activation in vivo in response to intracerebral administration of a xenopeptide. Exp Neurol 164: 362-370, 2000.          Abstract (HTML)          Full Text (PDF)

124. Rodrigues CM, Linehan Stieers C, Keene CD, Ma XM, Kren BT, Low WC, and Steer CJ: Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid evidence for a mitochondrial pathway independent of the permeability transition. J Neurochem 75: 2368-2379, 2000.          Abstract (HTML)          Full Text (PDF)

125. Solomon NP, McKee AS, Larson KJ, Tuite PJ, Eriksen S, Low WC, and Maxwell RE: Effects of pallidal stimulation on speech in three men with severe Parkinson's disease. American Journal of Speech-Language Pathology 9: 241-256, 2000.          Full Text (PDF)

126. Triarhou LC, Low WC, and Ghetti B, Neurological mutant mice as models in neural transplantation, In: Intracerebral Transplantation, Ed. by Q.Y. Wu and S.-S Jiao, The Science Press, Beijing, pp. 66-72 (2000).

127. Duan WM, Westerman M, Flores C, and Low WC: Survival of intrastriatal xenografts of ventral mesencephalic dopamine neurons from MHC-deficient mice to adult rats. Exp Neurol 167: 108-117, 2001.          Abstract (HTML)          Full Text (PDF)

128. Keene CD, Ni HT, and Low WC, Sus scrofa beta-2-microglobulin protein (B2M) gene, exons 1 through 4. GenBank Locus AF452448 (2001).

129. Kim KU, Ni HT, Spellman SR, Cho KH, Low WC, and Hall WA: Modulation of growth factor receptor expression by irradiation for Immunotoxin targeting. Methods Mol Biol 166: 101-110, 2001.

130. Kaemmerer WF, Rodrigues CMP, Steer CJ, and Low WC: Creatine-supplemented diets extends Purkinje cell survival in spinocerebellar ataxia type 1 transgenic mice but does not prevent the ataxic phenotype. Neuroscience 103:713-724 (2001).          Abstract (HTML)          Full Text (PDF)

131. Ni HT, Spellman SR, Jean WC, Hall WA, and Low WC: Immunization with dendritic cells pulsed with tumor extract increases survival of mice bearing intracranial gliomas. J Neurooncol 51: 1-9, 2001.          Abstract (HTML)          Full Text (PDF)

132. Lakkaraju A, Dubinsky JM, Low WC, and Rahman YE: Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. J Biol Chem 276: 32000-32007, 2001.          Abstract (HTML)          Full Text (PDF)

133. Keene CD, Rodrigues CMP, Eich T , Linehan-Stieers C, Abt A, Kren BT, Steer CJ, and Low WC: A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington?s disease. Exp Neurol 171: 351-360, 2001.          Abstract (HTML)          Full Text (PDF)

134. Tkac I, Keene CD, Pfeuffer J, Low WC, and Gruetter R: Metabolic changes in quinolinic acid-lesioned rat striatum measured non-invasively by in vivo 1H-NMR spectroscopy. J Neurosci Res 66: 891-898, 2001.          Abstract (HTML)          Full Text (PDF)

135. Wu AH and Low WC, Rattus Norvegicus familiaris interleukin 13 receptor alpha chain 2 IL13Ra2) mRNA, GenBank Locus NKIT432882 (2001).

136. Duan WM, Rodrigues CM, Zhao LR, Low WC and Steer CJ: Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson?s disease. Cell Transplant 11: 195-205, 2002.          Abstract (HTML)          Full Text (PDF)

137. Duan WM, Westerman M, Wong G, and Low WC: Rat nigral xenografts survive in the brain of MHC class II, but not class I deficient mice. Neuroscience 115: 495-504, 2002.          Abstract (HTML)          Full Text (PDF)

138. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez X, Reyes M, Lenvik T, Lund T, Blackstad M, Du JB, Aldrich S, Lisberg A, Low WC, Largaespada DA, and Verfaillie CM: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418: 41-49, 2002.          Abstract (HTML)          Full Text (PDF)

139. Keene CD, Rodrigues CMP, Eich T, Chhabra MS, Steer CJ, and Low WC: Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington?s disease. Proc Natl Acad Sci U S A 99: 10671-10676, 2002.          Abstract (HTML)          Full Text (PDF)

140. Rodrigues CM, Spellman SR, Sola S, Grande AW, Linehan-Stiers C, Low WC, and Steer CJ: Neuroprotection by a bile acid in an acute stroke model in the rat. J Cereb Blood Flow Metab 22: 463-471, 2002.          Abstract (HTML)          Full Text (PDF)

141. Wu AH and Low WC: Molecular cloning of the rat IL-13 alpha 2 receptor cDNA and its expression in rat tissues. J Neurooncol 59: 99-105, 2002.          Abstract (HTML)          Full Text (PDF)

142. Zhao LR, Duan WM, Reyes M, Keene CD, Verfaillie CM, and Low WC: Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Exp Neurol 174(1): 11-20, 2002.          Abstract (HTML)          Full Text (PDF)

143. Eriksen SK, Tuite PJ, Maxwell RE, Sullivan M, Low WC, Ebner TJ.  Bilateral subthalamic nucleus stimulation for the treatment of Parkinson’s disease: results of six patients.  J Neurosci Nurs 35(4): 223-231, 2003

144. Keene CD, Ortiz-Gonzalez XR, Jiang Y, Largaespada DA, Verfaillie CM, and Low WC.  Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos.  Cell Transplant 12:201-213 (2003). 

145. Kim KU, Xiao J, Ni HT, Cho KH, Spellman SR, Low WC, Hall WA.  Changes in expression of t ransferrin, insulin-like growth factor -1, and interleukin -4 receptors after irradiation of cells of primary malignant brain tumor cell lines.  Radiat Res 160(2) : 224-231, 2003. 

146. Rodrigues CM, Sola S, Nan Z, Castro RE, Ribeiro PS, Low WC, and Steer CJ: Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats.  Proc Natl Acad Sci USA 100(10): 6087-6092, 2003. 

147. Rustamzadeh E, Low WC, Vallera DA, and Hall WA, Immunotoxin therapy for CNS tumor, J Neuro-Oncol 64: 101-116, 2003. 

148. Wu AH and Low WC, Molecular cloning and Identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter, Neuro-Oncology 5(3): 179-187 (2003). 

149. Zhao LR, Duan WM, Reyes M, Verfaillie CM, and Low WC: Immunohistochemical identification of multipotent adult progenitor cells from human bone marrow after transplantation into the rat brain.  Brain Res Protoc 11: 38-45, 2003. 

150. Wu, AH and WC Low, Homo sapiens interleukin 13 receptor a2 (IL13RA2) gene, exon 2. GenBank Accession  AF473809 (2003).

 151. Wu, AH and WC Low, Homo sapiens interleukin 13 receptor a2 (IL13RA2) gene, promoter region and exon 1.  GenBank Accession AF473808 (2003).

152. Djalilian HR, Lessan K, Grami V, Pambuccian SE, Spellman SR, Low WC, Hall WA, and Ondrey FG, A new immune-competent animals model of mucossaly derived squamous cell carcinoma, Otolaryngology Head Neck Surgery, 131:781-783, (2004).

153. Graupman, P,  Pan D, Konair B, Hartung S, McIvor S, Whitley, C, Low WC, and Lam C, Craniofacial abnormalities in a murine knock-out model of MPS IH: A computed tomography anatomic study,  Craniofacial Surgery 15:392-398 (2004).

154. Hartung, SD, Frandsen JS, Pan D, Koniar, B, Graupman, P, Gunther, R, Low, WC, Whitley, CB, and McIvor RS, Correction of metabolic, craniofacial, and neurologic abnormalities in MPS I mice treated with adeno-associated virus transducing the human alpha-iduronidase gene, Molecular Therapy 9:866-875(2004).

155. Jean, WC, SR Spellman, MA Wallenfriedman, WA Hall, and WC Low, Granulocyte-macrophage colony-stimulating factor and interleukin-based immunotherapy against rat intracranial 9L glioma, Journal of Neuro-Oncology 66:39-49 (2004).

156. Ortiz-Gonzalez, X, CD Keene, CM Verfaillie, and WC Low, Neural Induction of adult bone marrow and umbilical cord stem cells, Current Neurovascular Research 1:207-213 (2004).

157. Tkac, I, Henry PG, Anderson P, CD Keene, WC Low, and R Gruetter, Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 Tesla, Magnetic Resonance in Medicine  52:478-484 (2004).

158. Wu AH, WA Hall, and WC Low, Identification of HLA a*0201 glioblastoma multiforme cell lines for immunotherapy by PCR-SSP and DNA sequencing, Journal of Neuro-Oncology 66:1-8 (2004).

159. Brustovetsky, N., R. LaFrance, K.J. Purl, T. Brustovetsky, C.D. Keene, W.C. Low, K.Chase, N. Aroni and J.M.Dubinsky, Age-dependent changes in the calcium sensitivity of striatal mitochondria in mouse models of Huntington's disease, Journal of Neurochemistry 93:1361-1370 (2005).

160. Chen Z, Kren BT, Wong PYP, Low WC, and Steer CJ,  Sleeping beauty mediated down-regulation of huntingtin expression by RNA interference, Biophysical and Biochemical Communications, 329:646-652 (2005).

161. Keene CD, Ortiz-Gonzalez XR, Jiang Y, Verfaillie CM, and Low WC, Therapeutic application of bone marrow- derived stem cells in neuralgic injury and disease. In: Cell Therapies for Central Nervous System Disorders, Ed. by P.R. Sanberg, Humana Press (in press, 2005).

162. Lam CH, Sethi KA and Low WC, A morphometric, neuroanatomic, and behavioral study on the effect of geometric constraint on the growing brain: the methyl-2-cyanoacrylate craniosynostosis model, Journal of Neurosurgery (Pediatrics), 102:396-402 (2005).

163. Nan, ZH, , Grande A, Sanberg CD, Sanberg PR, and Low WC, Infusion of human umbilical cord blood ameliorates neurologic deficits in rats with hemorrhagic brain injury, Annals of the New York Academy of Sciences, 1049:84-96 (2005).

164. Ohlfest JR, Demorest ZL, Motooka Y, Vengco I, Oh S, Chen E, Scappaticci FA, Saplis RJ, Ekker SC, Low WC, Freese AB, and Largaespada DA. Combinatorial antiangiogenic gene therapy by nonviral gene transfer using the Sleeping Beauty transposon causes tumor regression and improves survival in mice bearing intracranial human glioblastoma. Molecular Therapy 12:778-788(2005).

165. Xiao, J, Nan ZH, Motooka, Y, and Low, WC, Transplantation of a novel cell line population of umbilical cord blood stem cells ameliorates neurological deficits associated with ischemic brain injury, Stem Cells and Development 14:722-733 (2005).

166. Zhao LR, Spellman, Duan WM, McCarthy JB, and Low WC, Synthetic fibronectin peptide exerts neuroprotective effects on transient focal brain ischemia in rats. Brain Research 1054:1-8 (2005).

167. Burns TC, Ortiz-Gonzalez XR, Gutierrex-Perez M, Keene CD, Sharda R, Demorest ZL, Jiang Y, Nelson-Holte M, Soriano M, Nakagawa Y, Luquin MR, Garcia-Verdugo JM, Prosper F, Low WC, Verfaillie CM, Thymidine Analogs are Transferred from Pre-Labeled Donor to Host Cells in the Central Nervous System After Transplantation: A Word of Caution.Stem Cells 24:1121-7 (2006).

168. Rustamzadeh, E, Hall WA, Todhunter D, Low WC, Liu H, Panoskaltsis-Mortari A, and Vallera DA, Intracranial therapy of glioblastoma with the fusion protein DTIL13 in immunodeficient mice, International Journal of Cancer 118(10):2594-601 (2006).

169. Rustamzadeh E, Vallera DA, Todhunter D, Low WC, Panoskaltsis-Mortari A, and Hall WA,  Immunotoxin pharmacokinetics: A comparison between the anti-glioma bi-specific fusion protein (DTAT13) to DTAT and DTIL13, Journal of Neuro-Oncology 77(3):257-66 (2006).

170. Sam TN, Roehrich H, Xiao, J, Low WC, and Gregerson DS Tissue-restricted expression of a reporter gene associated with differentiated retinal photoreceptor cells by engrafted neural stem cells that home to retina, Cell Transplantation 15:147-60 (2006).

171. Tkac I, Dubinsky JM, Keene CD, Gruetter R, and Low WC,  Neurochemical Changes in Huntington R6/2 Mouse Striatum Detected by In Vivo 1H NMR Spectroscopy, Journal of Neurochemistry (in press, 2006).

172. Wu AH, J Xiao, L. Anker, WA Hall, DS Gregerson, WK Cavenee, W Chen, and WC Low, Identification of EGFRvIII-derived epitopes restricted by HLA A0201 for dendritic cell based immunotherapy of gliomas, Journal of Neuro-Oncology 76:23-30 (2006).

173. Wu AH, Wiesner S, Xiao J, Ericson K, Chen W, Hall WA, Low WC, and Ohlfest JR, Expression of MHC I and NK ligands on human CD133+ glioma cells: possible targets of immunotherapy, Journal of Neuro-Oncology (in press, 2006).