Ann M. Parr, MD, PhD

Assistant Professor, Department of Neurosurgery

Ann M. Parr

Contact Info

amparr@umn.edu

Mailing Address:
Department of Neurosurgery
MMC 96
420 Delaware St. SE
Minneapolis, MN 55455

Administrative Assistant Name
Claire Graham

Administrative Phone
612-624-6666

Administrative Email
clgraham@umn.edu

Assistant Professor, Department of Neurosurgery

Director, Spinal Neurosurgery


Neurosurgeon


Medical School, Queens University

Residency, University of Toronto (Neurosurgery)

Fellowship, University of Miami (Complex Spine)

PhD, Institute of Medical Science, Clinical Investigator Program, University of Toronto, Canada

Summary

Awards & Recognition

  • Rothenberger Emerging Physician Leadership Program, September 2017 - July 2019
  • Visiting Professor, Stanford University Department of Neurosurgery, January 2018
  • Visiting Professor, RUWINS, Rutgers University, NJ, April 2017
  • Research Education, Training, and Career Development (CTSI-Ed) Poster Competition Award, 2014
  • Paul Harris Fellow, The Rotary Foundation of Rotary International, 2013
  • AAMC Early Career Women Faculty Professional Development Award, 2011
  • AANS/CNS Cahill Spine Fellowship, 2009 - 2010
  • SPINEFEST Poster Competition first prize, 2008
  • AANS/CNS Section on Disorders of the Spine and Peripheral Nerves - Mayfield Basic Science Award, 2008
  • Regional Award Winner – ACS Trauma Competition, 2007

Professional Associations

  • American Association of Neurological Surgeons, 2004 – Present
  • Congress of Neurological Surgeons, 2000 – Present
  • Council of State Neurosurgical Societies
  • International Society of Stem Cell Research, 2004 – Present
  • Minnesota Neurosurgical Society
  • AANS/CNS Joint Section on Women in Neurosurgery, 2000 – Present
  • National Neurotrauma Society 2003 – Present

Research

Research Summary/Interests

Dr. Parr's research currently centers around transplanting neural stem cells grown from a patient's own skin into the injured spinal cord. She has an active translational research laboratory at the Stem Cell Institute. She is interested in examining mechanisms of functional recovery using techniques such as histology and immunohistochemistry, cell tracking through magnetic resonance imaging, and animal modeling.

Research Funding Grants

  • Morton Cure Paralysis Foundation, “Precision Placement of Spinal Neural Progenitor Cells in Patient-Specific 3D Bio-printed Scaffolds for Chronic Spinal Cord Injury Repair,” PI, 3/1/18 – 2/28/19
  • University of Minnesota Seed Grant, “3D Bioprinting Functionalized Motor Units for Spinal Cord Injury Repair,” PI, 7/1/17 – 6/30/18
  • Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant Program, “Precision Placement of Spinal Neural Progenitor Cells in Patient-Specific 3D Bio-Printed Scaffolds for Chronic Spinal Cord Injury Repair,” PI, 7/21/17 - 6/30/18
  • Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant Program, “Epidural stimulation in chronic spinal cord injury,” Co-I, (PI-Uzma Samadani & David Darrow), 7/1/16 - 6/30/18
  • Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant Program, “Epidural stimulation in chronic spinal cord injury,” Co-I, (PI-David Balzar), 7/1/16 - 6/30/18
  • Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant Program, “Oligodendrocyte Progenitor Cells and Scar Ablation for the Treatment of Chronic Spinal Cord Injury,” PI, 2/1/16 - 6/30/18
  • Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant Program, “Accelerating the differentiation of human pluripotent stem cells to treat spinal cord injury,” Co-I (PI: James Dutton), 7/21/17 – 6/30/18
  • Hennepin Healthcare (formerly Hennepin County Medical Center)/Minneapolis Medical Research Foundation, “Optimizing Epidural Spinal Cord Stimulation to Restore Cardiovascular Function after Spinal Cord Injury,” Co-I (PI: David Darrow), 7/1/17 – 6/30/18
  • University of Minnesota Foundation, “Autologous Oligodendrocyte Progenitor Cells for Transplantation in Spinal Cord Injury,” PI, 11/1/11 – present

Patents

  • “Acceleration of Stem Cell Differentiation,” Inventors: Patrick Walsh, James R. Dutton, Ann M. Parr. (Provisional)
  • “Composition and Methods for Chimeric Embryo-Assisted Organ Production,” Inventors: Atsushi Atsakura, Raj Aravalli, Maxin Cheeran, James Dutton, Daniel Garry, Mary Garry, Melanie Graham, Ling Li, Walter Low, Angela Panoskaltsis-Mortari, Timothy O’Brien, Clifford Steer, Jakub Tolar, Daniel Carlson, Scott Fahrenkrug, Naoko Koyano-Nakagawa, Ann M. Parr (Provisional)

Publications

Book Chapters

  • Parr AM , Gupte A, (2016) 50 Studies Every Spine Surgeon Should Know, A review of surgical versus nonsurgical treatment for lumbar degenerative spondylolisthesis, by Weinstein et al. 
  • Walsh P, K Voltzke, Parr AM, Dutton JR (2015) cGMP Production of Human iPS Cells, AABB Cellular Therapy: Principles, Methods, and Regulations, 2nd edition

Lectures Online
"New Therapies for Spinal Cord Injuries", March 7, 2011

Publications (most recent)

  • Patil N, Truong V, Dutton J, Holmberg E, and Parr AM. Safety and Efficacy of Rose Bengal Derivatives for Glial Scar Ablation in Chronic Spinal Cord Injury, accepted to Journal of Neurotrauma, January 2018
  • Walsh P, Truong V, Hill C, Stoflet ND, Baden J, Low WC, Keirstead S, Dutton JR*, Parr AM*. Defined culture conditions accelerate small-molecule assisted neural induction for the production of neural progenitors from human induced pluripotent stem cells, Accepted to Cell Transplantation, October 2017
  • Levi AD, Okonkwo DO, Park P, Jenkins AL 3rd, Kurpad SN, Parr AM, Ganju A, Aarabi B, Kim D, Casha S, Fehlings MG, Harrop JS, Anderson KD, Gage A, Hsieh J, Huhn S, Curt A, Guzman R. Emerging safety of intramedullary transplantation of human neural stem cells in chronic cervical and thoracic spinal cord injury, Neurosurgery, May 2017. PMID: 28541431
  • Parr AM, Walsh PJ, Truong V, Dutton JR. cGMP-Compliant Expansion of Human iPSC Cultures as Adherent Monolayers, Methods in molecular biology (Clifton, N.J.). 2016; 1357:221-9. PubMed [journal], PMID: 25863788
  • Satzer D, Miller C, Maxon J, Voth J, DiBartolomeo C, Mahoney R, Dutton JR, Low WC and Parr AM. T Cell Deficiency in Spinal Cord Injury: Altered Locomotor Recovery and Whole-Genome Transcriptional Analysis. BMC Neuroscience. 2015; 16:74. DOI: 10.1186/s12868-015-0212- 0, PMID 26546062
  • Terzic D, Maxon J, Krevitt L, DiBartolomeo C, Goyal T, Lea K, Low WC, Dutton JR, and Parr AM. Directed Differentiation of Oligodendrocyte Progenitor Cells From Mouse Induced Pluripotent Stem Cells, Cell Transplantation, May 2015. PMID: 25955415
  • Satzer D, DiBartolomeo C, Ritchie MM, Storino C, Liimatainen T, Hakkarainen H, Idiyatullin D, Mangia S, Michaeli S*, Parr AM*, Low WC*. Assessment of dysmyelination with RAFFn MRI: Application to murine MPS I. PlosOne 2015 Feb 13; 10(2):e0116788 *co-senior authors. PMID: 25680196
  • Parr AM, Kulbatski I, Wang XH, Keating A, and Tator CH. Fate of transplanted adult neural stem/progenitor cells and bone marrow-derived mesenchymal stromal cells in the injured adult rat spinal cord and impact on functional recovery. Surg Neurol 70(6) 600-7, 2008. PMID: 18291482
  • Parr AM, Kulbatski I, Zahir T, Wang X, Yue C, Keating A, and Tator CH. Transplanted adult spinal cord-derived neural stem/progenitor cells promote early functional recovery after rat spinal cord injury. Neuroscience 155(3) 760-70, 2008. PMID: 18588947
  • Kulbatski I, Mothe AJ, Parr AM, Kim H, Kang CE, Bozkurt G, and Tator CH. Glial precursor cell transplantation therapy for neurotrauma and multiple sclerosis. Prog Histochem Cytochem 43(3) 123-76, 2008. PMID: 18706353

Posters and Abstracts (most recent)

  • Patil N, Truong V, Stoflet N, Holmberg E, Parr AM. Safety and Efficacy of Rose Bengal Derivatives for Glial Scar Ablation in Chronic Spinal Cord Injury. Minnesota SCI & TBI Research Symposium, January 2018
  • Walsh P, Parr AM, Dutton JR. Human Pluripotent Stem Cell Differentiation into Spinal Cord Neural Progenitors. Minnesota SCI & TBI Research Symposium, January 2018
  • Voth J, Low W, Parr AM. Olig1/2 Knockout Blastocyst Complementation to Generate Oligodendrocytes. Regenerative Medicine Minnesota Annual Meeting 2017
  • Voth J, Low W, Parr AM. Olig1/2 Knockout Blastocyst Complementation to Generate Oligodendrocytes. Peyton Society Meeting, Minneapolis, MN, July 2017
  • Voth J, Low W, Parr AM. Olig1/2 Knockout Blastocyst Complementation to Generate Oligodendrocytes. Institute of Engineering in Medicine Annual Meeting 2016
  • Parr AM, Clinical and Translational Science Institute (CTSI) Poster Day, 2015-2016
  • Parr AM, Dutton J. Clinically Relevant Human Motor Neuron Progenitor Cells for the Treatment of Spinal Cord Injury. Clinical and Translational Science Institute. Minneapolis, MN, February 2016
  • Parr AM, Subramaniam S, Mahoney R, Truong V, Maxon J, Krevitt L, Walsh P, McKenna D, Dutton JR. Engineering hiPSC-derived Oligodendrocyte Progenitor Cells for Autologous Treatment of Chronic Spinal Cord Injury. 2015 Wings for Life Annual Conference, Vienna, Austria
  • Parr AM, Subramaniam S, Mahoney R, Truong V, Maxon J, Krevitt L, Walsh P, McKenna D, Dutton JR. Manufacturing hiPSC-derived Oligodendrocyte Progenitor Cells for Autologous Therapy. Association for Clinical Translation Science Meeting, Washington DC, 2015, 2016
  • Mahoney R, Subramaniam S, Maxon J, Truong V, Krevitt L, Walsh P, Dutton J, Parr AM. In vivo Tracking of iPS cell derived Oligodendrocyte Progenitor Cells in the Injured Spinal Cord Using 19Fluorine MRI. 2nd Annual Regenrative Medicine Meeting, University of Minnesota, 2014.

Clinical

Specialties

  • Neurosurgery

Clinics

Neurosurgery Clinic

Board Certifications

  • FRCSC (Fellow of the Royal College of Surgeons of Canada)
  • FAANS (Fellow of the American Association of Neurological Surgery) 

Clinical Interests

Spine; General neurosurgery; Complex spinal surgery; Minimally invasive spinal surgery